In Vegas Dream for the NES, you and up to three friends head for Las Vegas in hopes of winning up to $1,000,000. You begin the game with $700.00, and you must challenge your friends or the house to Blackjack, Roulette, Slot Machines, or Keno. Throughout the course of the game, you will encounter a variety of strangers, both good and bad. The people who approach you will be looking for side bets, trying to hustle you, looking for romance, or trying to win your pity with their hard luck stories.

The One Spot mode of play features the same four games as the aforementioned Vegas Dream mode, but without the storyline and strangers. In either mode of play, a password feature enables you to continue a game in progress at a later time.