Simpsons: Bart vs. the Space Mutants is a side scrolling action adventure set in scenic Springfield. As Bart, you will run and jump through five levels of action in order to stop the dangerous space mutants that threaten Springfield. Only Bart knows their dastardly plan, and only Bart has the irreverent nature necessary to this task. More importantly, only Bart has the X-ray spectacles that distinguish the cleverly disguised space mutants from the general populous.

Bart picks up a variety of useful items along his journey; and as you would expect, a whole host of "Simpsons" characters enhance the atmosphere of this cartoon adventure. Notably, Bart meets Principal Skinner, Nelson and Moe.